Only Reload, yes! Or else you will not get updated block list from the servers until you reload or reboot. It works anyway but the internet is a moving target and it doesn’t wait for you to catch up.
Do not use start or autostart in the cron job, the result will not be what you expected.
Reload downloads new blocklists and load them in the program.
I'm asking because I saw the app and after rebooting the router I saw that there was nothing in logs and Blocked Domains was 0, that's why I'm asking whether there could be another option I'm missing to set