The way I understand the question:
* There are at least two access points.
* The access points are connected by wire to share at least a guest vlan.
* Those access points span individual Wifi SSIDs for that guest network.
* The "client isolation" feature joky has already working: A client connected to Guest-Wifi on AP1 is unable to communicate to a client to connect to GuestWifi on the very same AP1.
* The "client isolation" feature joky wants to have is: A client connected to Guest-Wifi on AP1 should not be able to communicate to a client to connect to GuestWifi on a different AP2.
My answer: No.
The point is: The "client isolation" feature you're referring to is a mechanism of the wifi configuration which does not work as soon as there is one communication partner involved which is not connected by wifi but by wire. This forces the traffic to leave the domain of wifi and to enter the domain of the switch. And (at least in the world of OpenWRT) there is no such thing as client isolation on switches.
As soon as at least one communication partner is connected not by Wifi but by wire, there is no such thing as client isolation.
This goes for
* All clients are connected by wire
* One client is connected by wire and another one is connected by Wifi
* Both are connected by Wifi on different APs but the APs are connected by wire
Given the scenario of having
* Client1 connected to AP1 by Wifi,
* Client2 is connected to AP2 by wifi and
* AP1 and AP2 are connected by wire.
In that situation, AP1 sees Client2 to be connected by wire, so "from Client1 to Clint2" means 1 is wifi but 2 is wire, as well as AP2 sees Client1 to be connected by wire, so "from Client2 to Client1" means 2 is wifi but 1 is wire. In both situations, one of the communication partners appears to the other as "by wire".
And "client isolation" only works for Wifi.
(1x) BananaPi M1 ; (3x) TP-Link WDR4900 ; (2x) TP-Link WR1043N ; (1x) TP-Link WDR4300 ; (1x) Netgear WNR3500L ; (1x) Virtual on ESX ; (1x) Virtual on Virtualbox on OS-X
6 VLANs and 3 SSIDs power my home