HOLD ON ONE SECOND...YOU JUST MENTIONED:
So, is Wireguard setup on an LEDE? And if so, now explain the SERVER is involved? Is this server at a remote location?
You must open the firewall wherever you are passing the traffic. Therefore, please describe the whole connection:
- What devices are running Wireguard?
- What devices/firewalls/networks/Internet are in between these devices?
- What port did you use for Wireguard?
(if you are in fact running Wireguard on the LEDE, that inbound rule looks OK.)
This thread may also help: [Solved] Wireguard as a VPN "server"