Openwrt from USB

As a router i use a nanopi r2s, it is booting from MicroSD.
With my new setup i want to boot openwrt from USB, does anybody know if it is possible to boot from USB without needing the SD card?

Depends on the device, not really openwrt.

In worst case, put a boot loader on a SD, then boot the OS from the USB flash drive, via the SD.

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