Short term, I don't think there is much you can do. I'm guessing ditching the wireless bridge and connecting your AP via a wire is not an option you want.
For the purpose of a test, you could rearrange your AP's such that the r7500v2 is connected to your isp via wire, temporarily turn off the bridge, and test just using 5 GHz as an AP only. But this will only confirm that post v19, wifi throughput variation increases (I call it throughput jitter).
You could also try the v19 ath10k-ct firmware on v21 or v22. If there is an improvement with v19 ath10k-ct firmeware, you can ask for assistance from the ct dev but you will likely have to spend a fair amount of time working with them.
EDIT: you can also try disabling AQL on v21 or v22
echo 0 > /sys/kernel/debug/ieee80211/phy0/aql_enable
echo 0 > /sys/kernel/debug/ieee80211/phy1/aql_enable
REF
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